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KMID : 0380020040190030178
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Korean Journal of Biotechnology and Bioengineering
2004 Volume.19 No. 3 p.178 ~ p.186
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Preparation and Application of Whitening Ingredient Entrapped in Solid Lipid Nanoparticle [SLN]
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Han Sung-Cheol
Kim Yeon-Ju
Lee Ki-Young
Kim Dong-Woon
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Abstract
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The aim of this study was to investigate the skin-whitening effect of okyong-san and to develop new drug delivery carrier The extracts of okyong-san were found to have the whitening effect and Eudragitⓡ/ L 100-55 (EUD) coated solid lipid nanoparticle (E-SLN) was prepared by solvent evaporation method and melt dispersion technique. As a result, E-SLN have a 144-170 nm of particle size, spherical shape, and 33-41% encapsulation efficiency, After release test in vitro, release profile of E-SLN depended on pH and temperature. Lastly, closed patch test and skin-whitening test was peformed clinically. In conclusion, test sample had non-stimulation and high % whiteness. The results suggest that okyong-san and E-SLN is useful as cosmeceuticals for whitening cosmetics.
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KEYWORD
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SLN, okyong-san, eudragit, encapsulation, cosmetics
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